In this new context, we aimed to reassess the value of conventional risk factors with regard to new genetic alterations and early response to therapy, as assessed by immunoglobulin/T- cell receptor minimal residual disease (MRD) levels. The study was performed in 4. Philadelphia chromosome- negative ALL in first remission (2. B- cell precursor . In addition to conventional risk factors, the most frequent currently available genetic alterations were included in the analysis. A higher specific hazard of relapse was independently associated with postinduction MRD level . These 2 factors allowed definition of a new risk classification that is strongly associated with higher CIR and shorter relapse- free and overall survival. These results indicate that genetic abnormalities are important predictors of outcome in adult ALL not fully recapitulated by early response to therapy. Patients included in this study were treated in the multicenter GRAALL- 2. Arts & Humanities; Beauty & Style; Business & Finance; Cars & Transportation; Computers & Internet; Consumer Electronics. X-Ray Technique Charts? Canadian Journal for the Study of Adult Education = la Revue canadienne pour l'etude de l'education des adultes. ERIC Educational Resources Information Center. Full text of 'The New Schaff Herzog Encyclopedia Of Religious Knowledge Volume XI Son Of Man Tremellius' See other formats. GRAALL- 2. 00. 5 trials. Both trials were registered at http: //www. NCT0. 02. 22. 02. NCT0. 03. 27. 67. PMID: 2. 47. 40. 80. Childhood- Onset Disease Predicts Mortality in an Adult Cohort of Patients with Systemic Lupus Erythematosus. Pub. Med Central. Hersh, Aimee O.; Trupin, Laura; Yazdany, Jinoos; Panopalis, Peter; Julian, Laura; Katz, Patricia; Criswell, Lindsey A.; Yelin, Edward. Objective To examine childhood- onset disease as a predictor of mortality in a cohort of adultpatients with systemic lupus erythematosus (SLE). Methods Data were derived from the University of California Lupus Outcomes Study, a longitudinal cohort of 9. SLE that includes 9. Definium 5000 Manual Arts Crenshaw
SLE. Baseline and follow- up data were obtained via telephone interviews conducted between 2. The number of deaths during 5 years of follow- up was determined and standardized mortality ratios (SMRs) for the cohort, and across age groups, were calculated. Kaplan- Meier life table analysis was used to compare mortality rates between childhood (defined as SLE diagnosis < 1. SLE. Multivariate Cox proportional hazard models were used to determine predictors of mortality. Results During the median follow- up period of 4. SLE. The overall SMR was 2. CI 2. 0- 3. 2). In Kaplan- Meier survival analysis, after adjusting for age, childhood- onset subjects were at increased risk for mortality throughout the follow- up period (p< 0. In a multivariate model adjusting for age, disease duration and other covariates, childhood- onset SLE was independently associated with an increased mortality risk (hazard ratio . Conclusion Childhood- onset SLE was a strong predictor of mortality in this cohort. Interventions are needed to prevent early mortality in this population. PMID: 2. 02. 35. 21. Oncogenetics and minimal residual disease are independent outcome predictors in adultpatients with acute lymphoblastic leukemia. Pub. Med. Beldjord, Kheira; Chevret, Sylvie; Asnafi, Vahid; Huguet, Fran. In this new context, we aimed to reassess the value of conventional risk factors with regard to new genetic alterations and early response to therapy, as assessed by immunoglobulin/T- cell receptor minimal residual disease (MRD) levels. The study was performed in 4. Philadelphia chromosome- negative ALL in first remission (2. Queensland recognises outstanding achievement through its Awards for. Contractors Definium Surveyors Landgraphics. 5,000 tonnes of Greenhouse gas. All work shall comply with the latest edition of the USACE Safety and Health Requirements Manual, EM385-1-1. EAST 11 MILE ROAD Warren MI 48397-5000. Since its inception, Urban Developer magazine has become the Queensland development industry. Working directly with the Urban. Arts & Entertainment Style & Fashion Home & Garden Business Travel. Contract # Mod # Ref # Subject: Contact Agency: Vendor: Pop Zip: Total: Set Aside: NAICS: Award Date: Est Completion Date: Last Modified By: VA69D15J2923: P00002. B- cell precursor . In addition to conventional risk factors, the most frequent currently available genetic alterations were included in the analysis. A higher specific hazard of relapse was independently associated with postinduction MRD level . These 2 factors allowed definition of a new risk classification that is strongly associated with higher CIR and shorter relapse- free and overall survival. These results indicate that genetic abnormalities are important predictors of outcome in adult ALL not fully recapitulated by early response to therapy. Patients included in this study were treated in the multicenter GRAALL- 2. GRAALL- 2. 00. 5 trials. Both trials were registered at http: //www. NCT0. 02. 22. 02. NCT0. 03. 27. 67. Management of adultpatients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro- Histio- Net. Pub. Med. Girschikofsky, Michael; Arico, Maurizio; Castillo, Diego; Chu, Anthony; Doberauer, Claus; Fichter, Joachim; Haroche, Julien; Kaltsas, Gregory A; Makras, Polyzois; Marzano, Angelo V; de Menthon, Mathilde; Micke, Oliver; Passoni, Emanuela; Seegenschmiedt, Heinrich M; Tazi, Abdellatif; Mc. Clain, Kenneth L2. Langerhans Cell Histiocytosis (LCH) is an orphan disease of clonal dendritic cells which may affect any organ of the body. Most of the knowledge about the diagnosis and therapy is based on pedriatic studies. Adult LCH patients are often evaluated by physicians who focus on only the most obviously affected organ without sufficient evaluation of other systems, resulting in patients being underdiagnosed and/or incompletely staged. Furthermore they may be treated with pediatric- based therapies which are less effective and sometimes more toxic for adults. The published literature on adult LCH cases lacks a comprehensive discussion on the differences between pediatric and adultpatients and there are no recommendations for evaluation and comparative therapies. In order to fill this void, a number of experts in this field cooperated to develop the first recommendations for management of adultpatients with LCH. Key questions were selected according to the clinical relevance focusing on diagnostic work up, therapy, and follow up. Based on the available literature up to December 2. The quality of evidence of the recommendations is predominantly attributed to the level of expert opinion. Final agreement was by consensus. PMID: 2. 36. 72. 54. Management of adultpatients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro- Histio- Net. Pub. Med Central. Langerhans Cell Histiocytosis (LCH) is an orphan disease of clonal dendritic cells which may affect any organ of the body. Most of the knowledge about the diagnosis and therapy is based on pedriatic studies. Adult LCH patients are often evaluated by physicians who focus on only the most obviously affected organ without sufficient evaluation of other systems, resulting in patients being underdiagnosed and/or incompletely staged. Furthermore they may be treated with pediatric- based therapies which are less effective and sometimes more toxic for adults. The published literature on adult LCH cases lacks a comprehensive discussion on the differences between pediatric and adultpatients and there are no recommendations for evaluation and comparative therapies. In order to fill this void, a number of experts in this field cooperated to develop the first recommendations for management of adultpatients with LCH. Key questions were selected according to the clinical relevance focusing on diagnostic work up, therapy, and follow up. Based on the available literature up to December 2. The quality of evidence of the recommendations is predominantly attributed to the level of expert opinion. Final agreement was by consensus. PMID: 2. 36. 72. 54. The relationship between organ dose and patient size in tube current modulated adult thoracic CT scans. NASA Astrophysics Data System (ADS)Khatonabadi, Maryam; Zhang, Di; Yang, Jeffrey; De. Marco, John J.; Cagnon, Chris C.; Mc. Nitt- Gray, Michael F. Recently published AAPM Task Group 2. CTDIvol to estimate dose to the center of patient undergoing fixed tube current body exam. However, most performed CT exams use TCM to reduce dose to patients. Therefore, the purpose of this study was to investigate the correlation between organ dose and a variety of patient size metrics in adult chest CT scans that use tube current modulation (TCM). Monte Carlo simulations were performed for 3. These simulations made use of patient's actual TCM data to estimate organ dose. Using image data, different size metrics were calculated, these measurements were all performed on one slice, at the level of patient's nipple. Estimated doses were normalized by scanner- reported CTDIvol and plotted versus different metrics. CTDIvol values were plotted versus different metrics to look at scanner's output versus size. The metrics performed similarly in terms of correlating with organ dose. Looking at each gender separately, for male models normalized lung dose showed a better linear correlation (r. There was essentially no correlation observed between size and CTDIvol- normalized breast dose. However, a linear relationship was observed between absolute breast dose and size. Dose to lungs and breasts were consistently higher in females with similar size as males which could be due to shape and composition differences between genders in the thoracic region. Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy. Pub. Med. Redei, E E; Andrus, B M; Kwasny, M J; Seok, J; Cai, X; Ho, J; Mohr, D C2. An objective, laboratory- based diagnostic tool could increase the diagnostic accuracy of major depressive disorders (MDDs), identify factors that characterize patients and promote individualized therapy. The goal of this study was to assess a blood- based biomarker panel, which showed promise in adolescents with MDD, in adult primary care patients with MDD and age- , gender- and race- matched nondepressed (ND) controls. Patients with MDD received cognitive behavioral therapy (CBT) and clinical assessment using self- reported depression with the Patient Health Questionnaire- 9 (PHQ- 9). The measures, including blood RNA collection, were obtained before and after 1. CBT. Blood transcript levels of nine markers of ADCY3, DGKA, FAM4. A, IGSF4. A/CADM1, KIAA1. MARCKS, PSME1, RAPH1 and TLR7, differed significantly between participants with MDD (N=3. ND controls (N=3. Abundance of the DGKA, KIAA1. RAPH1 transcripts remained significantly different between subjects with MDD and ND controls even after post- CBT remission (defined as PHQ- 9 < 5).
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